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#4174 TPA (12-O-Tetradecanoylphorbol-13-Acetate)

 
  • TPA (12-O-Tetradecanoylphorbol-13-Acetate) Data Sheet PDF
CSTコード 包装
希望納入価格 (円)
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2019年12月13日15時35分 現在
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#4174S1 mg18,000
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概要
TPA は強力な発がんプロモーターで、プロテインキナーゼ C に結合、活性化して細胞や組織にさまざまな作用を引き起こします。
分子量 
616.84
分子の化学式
C36H56O8
貯法
-20℃
社内データ

Western Blotting

Western Blotting

Western blot analysis of extracts from serum-starved 293 cells, untreated (lane 1), stimulated with TPA treatment (lanes 2 & 3), and treated with CIP and λ phosphatase (lane 3), using Phospho-PKC (pan) (βII Ser660) Antibody #9371 or PKCα Antibody #2056.

Western Blotting

Western Blotting

Western blot analysis of extracts from serum-starved 293 cells, untreated (lane 1), stimulated with TPA treatment (lanes 2 & 3), and treated with CIP and λ phosphatase (lane 3), using Phospho-PKD/PKCμ (Ser916) Antibody #2051 or PKD/PKCμ Antibody #2052.

バックグラウンド

TPA (12-O-tetradecanoylphorbol-13-acetate) / PMA (phorbol-12-myristate-13-acetate) is the most commonly used phorbol ester. It binds and activates protein kinase C, causing a wide range of effects in cells and tissues (1,2). TPA has been demonstrated to be a potent tumor promoter in mouse skin (3). Conversely, it has been shown to be an effective cancer therapeutic agent in myelocytic leukemia patients, and has been indicated as a potential colorectal cancer therapeutic (4-5). TPA has also been shown to increase white blood cell and neutrophil counts in solid tumor cancer patients (6).

使用文献
 
関連製品
12611   DMSO (Dimethyl Sulfoxide), Sterile

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本製品は試験研究用です。

TPA (12-O-Tetradecanoylphorbol-13-Acetate)

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