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#2904 VEGF Receptor 2 Control Proteins

  • VEGF Receptor 2 Control Proteins Data Sheet PDF
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希望納入価格 (円)
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2019年8月23日15時25分 現在
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#2904S150 μL25,000
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VEGF2 製品一覧

調製方法
Nonphosphorylated VEGFR2 Control Proteins:λ phosphatase処理したヒトのVEGFR2 細胞の溶解物
Phosphorylated VEGFR2 Control Proteins:未処理のヒトのVEGFR2 細胞の溶解物
貯法
-20℃
MSDSはこちらから
バックグラウンド

Vascular endothelial growth factor receptor 2 (VEGFR2, KDR, Flk-1) is a major receptor for VEGF-induced signaling in endothelial cells. Upon ligand binding, VEGFR2 undergoes autophosphorylation and becomes activated (1). Major autophosphorylation sites of VEGFR2 are located in the kinase insert domain (Tyr951/996) and in the tyrosine kinase catalytic domain (Tyr1054/1059) (2). Activation of the receptor leads to rapid recruitment of adaptor proteins, including Shc, GRB2, PI3 kinase, NCK, and the protein tyrosine phosphatases SHP-1 and SHP-2 (3). Phosphorylation at Tyr1212 provides a docking site for GRB2 binding and phospho-Tyr1175 binds the p85 subunit of PI3 kinase and PLCγ, as well as Shb (1,4,5). Signaling from VEGFR2 is necessary for the execution of VEGF-stimulated proliferation, chemotaxis and sprouting, as well as survival of cultured endothelial cells in vitro and angiogenesis in vivo (6-8).

使用例
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2477   Phospho-VEGF Receptor 2 (Tyr1212) (11A3) Rabbit mAb
2478   Phospho-VEGF Receptor 2 (Tyr1175) (19A10) Rabbit mAb
2479   VEGF Receptor 2 (55B11) Rabbit mAb
3770   Phospho-VEGF Receptor 2 (Tyr1175) (D5B11) Rabbit mAb
3817   Phospho-VEGF Receptor 2 (Tyr1059) (D5A6) Rabbit mAb
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7074   Anti-rabbit IgG, HRP-linked Antibody
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本製品は試験研究用です。

VEGF Receptor 2 Control Proteins

Immune Cell Signaling Pathways

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