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#1083 Acetyl-Histone H3 (Lys9) Blocking Peptide

 
  • Acetyl-Histone H3 (Lys9) Blocking Peptide Data Sheet PDF
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希望納入価格 (円)
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2020年2月21日15時25分 現在
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HISTONE H3 製品一覧

用途
免疫組織染色
貯法
-20℃
使用目的
Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb (#9649) およびAcetyl-Histone H3 (Lys9) Antibody (#9671) の反応をブロックし、抗体の反応特異性を確認するために使用
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Modulation of chromatin structure plays an important role in the regulation of transcription in eukaryotes. The nucleosome, made up of DNA wound around eight core histone proteins (two each of H2A, H2B, H3, and H4), is the primary building block of chromatin (1). The amino-terminal tails of core histones undergo various post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (2-5). These modifications occur in response to various stimuli and have a direct effect on the accessibility of chromatin to transcription factors and, therefore, gene expression (6). In most species, histone H2B is primarily acetylated at Lys5, 12, 15, and 20 (4,7). Histone H3 is primarily acetylated at Lys9, 14, 18, 23, 27, and 56. Acetylation of H3 at Lys9 appears to have a dominant role in histone deposition and chromatin assembly in some organisms (2,3). Phosphorylation at Ser10, Ser28, and Thr11 of histone H3 is tightly correlated with chromosome condensation during both mitosis and meiosis (8-10). Phosphorylation at Thr3 of histone H3 is highly conserved among many species and is catalyzed by the kinase haspin. Immunostaining with phospho-specific antibodies in mammalian cells reveals mitotic phosphorylation at Thr3 of H3 in prophase and its dephosphorylation during anaphase (11).

使用例
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関連製品
9649   Acetyl-Histone H3 (Lys9) (C5B11) Rabbit mAb

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

本製品は試験研究用です。

Acetyl-Histone H3 (Lys9) Blocking Peptide

Immune Cell Signaling Pathways

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