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#1064 Tri-Methyl-Histone H3 (Lys4) Blocking Peptide

 
  • Tri-Methyl-Histone H3 (Lys4) Blocking Peptide Data Sheet PDF
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希望納入価格 (円)
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2019年9月13日15時30分 現在
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HISTONE H3 製品一覧

用途
免疫組織染色
貯法
-20℃
使用目的
Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb (#9751) およびTri-Methyl-Histone H3 (Lys4) Antibody (#9727) の反応をブロックし、抗体の反応特異性を確認するために使用
バックグラウンド

The nucleosome, made up of four core histone proteins (H2A, H2B, H3, and H4), is the primary building block of chromatin. Originally thought to function as a static scaffold for DNA packaging, histones have now been shown to be dynamic proteins, undergoing multiple types of post-translational modifications, including acetylation, phosphorylation, methylation, and ubiquitination (1). Histone methylation is a major determinant for the formation of active and inactive regions of the genome and is crucial for the proper programming of the genome during development (2,3). Arginine methylation of histones H3 (Arg2, 17, 26) and H4 (Arg3) promotes transcriptional activation and is mediated by a family of protein arginine methyltransferases (PRMTs), including the co-activators PRMT1 and CARM1 (PRMT4) (4). In contrast, a more diverse set of histone lysine methyltransferases has been identified, all but one of which contain a conserved catalytic SET domain originally identified in the Drosophila Su(var)3-9, Enhancer of zeste, and Trithorax proteins. Lysine methylation occurs primarily on histones H3 (Lys4, 9, 27, 36, 79) and H4 (Lys20) and has been implicated in both transcriptional activation and silencing (4). Methylation of these lysine residues coordinates the recruitment of chromatin modifying enzymes containing methyl-lysine binding modules such as chromodomains (HP1, PRC1), PHD fingers (BPTF, ING2), tudor domains (53BP1), and WD-40 domains (WDR5) (5-8). The discovery of histone demethylases such as PADI4, LSD1, JMJD1, JMJD2, and JHDM1 has shown that methylation is a reversible epigenetic marker (9).

使用例
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関連製品
9727   Tri-Methyl-Histone H3 (Lys4) Antibody
9751   Tri-Methyl-Histone H3 (Lys4) (C42D8) Rabbit mAb

Cell Signaling Technology is a trademark of Cell Signaling Technology, Inc.

本製品は試験研究用です。

Tri-Methyl-Histone H3 (Lys4) Blocking Peptide

Immune Cell Signaling Pathways

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